Nimesulide provides relief from primary dysmenorrhoea in adolescents & osteoarthritis. It’s a anti-inflammatory, non-steroidal drug. Nimusilide provides treatment for acute pain. But nimesulide has been drawn aside from the market because of its hepatic effects (risk of hepatatoxicity) on patients. In India this banned compound is still available easily. Because of the adverse reactions European countries & Israel has withdrawn nimesulide from market.
European countries have also banned the use of Nimesulide in view of its unacceptable rate of serious adverse reactions. Israel also withdrew the use of Nimesulide in 1999 after reports of several cases of severe hepatic failure.
Few of the trade names are:
Aulin, Ainex, Mesulid,Drexel, Edrigyl, Enetra, Eskaflam, Heugan, Donulide, Minapon, Nexen, Nimed, Nimedex, Nimesil, Nise,Nimulid, Nimutab, Nisulid, Nidolon,Nodard Plus (India), Scaflam, Scaflan etc.
Side effects of nimesulide:
- Use of nimesulide can cause hepatotoxic risks. It can happen not only in children but also in adults
- It can even cause liver injury.
- According to a few studies nimesulide should not be used for the primary mode of therapy as anti-pyretic, particularly for children.
- Study reveals that five day use of nimusulide (by a 70 year old women) cause jaundice & as per laboratory probes hypoglycaemia, hypoalbuminaemia. Coagulopathy were there. In spite of the treatment acute renal failure enlarged.
- Prolong use of nimesulide can developed gastritis.
- Through an action on COX-2 colon cancer can occur.
- Indigestion is one of the most common effect.
- Some other side effects that can be experienced are:
- Headache, skin rash, vomiting, diarrhoea, dizziness & pruritis.
- Pregnant women or women in lactation should consult a doctor before having this drug.