What is Coagulation? Or Clotting of Blood


Coagulation is process by which blood is clot and then heals a cut and stops the bleeding. It is also a complicated part of Hemostasis. It stops blood loss from damaged blood vessels. In Hemostasis a damaged blood vessel is blocked by a Platelet and clot of fibrin stops the bleeding and the damage is repaired.

Coagulation consists of Platelets and the Protein components.

When a lining of the blood vessel is damaged, Platelets form a membrane at the place of injury and proteins in the Blood Plasma chemically reacts to form fibrin that forms the Platelet covering.

There are two types of Hemostasis:

1. Primary Hemostasis
2. Secondary Hemostasis

Primary Hemosatsis
It occurs when the platelets appear at the site of injury to block it.

Secondary Hemostasis
In this process the Proteins chemically reacts to strengthen the blockage and begins the healing process.

It is a disc shaped element in the blood that helps in clotting of blood. They are also grouped as blood cells.

It is a protein that helps in blood clotting. It deposits around an injury in a form of net to strengthen the platelets. It dries and becomes hard to stop the clotting and then it heals the wound.

When platelets contacts with the damaged tissue then chemical reactions occur that forms the Fibrin from Fibrinogen.

Coagulation Factors (Clotting Factors)

Coagulation factors are proteins which are produced by liver. There are numbered in the order of their discovery. They are named after Roman Numerals from I-XIII. There are many proteins that help in blood clotting and they are not given numbers rather they are named as others.


When a wall of blood vessel is damaged or an injury occurs, much type of chemical reactions take place that involves coagulation factors.

The last step of chemical reaction Fibrinogen is converted in to Fibrin that forms a net like structure and transforms blood cells in to solid clot, blocking the hole and stops the bleeding.

Patients with hemophilia A have the deficiency of Factor VIII and patients with hemophilia B have deficiency of Factor IX.

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