Premixed Insulin Provides Better Glycemic Control

Premixed insulin, combination of short and long-acting kinds of the hormone, provides better blood-sugar control in comparison with long-acting insulin alone or oral therapies, a new study finds.

Two types of premixed insulin — premixed human insulin and premixed insulin analogues (human insulin which is genetically engineered), appeared to have the same advantages.

Around 28 percent of type 2 diabetes patients use insulin alone (16 percent) or combined with an oral medication (12 percent) to maintain their blood-glucose levels.

And as the number of type 2 diabetes patient are increasing, awareness on the effectiveness and safety of premixed insulin is even more essential.

Premixed insulin consists of both long and short-acting insulin together in one preparation. These products provide patients more flexibility as to when they eat.

“This is supposed to treat the post-meal sugar and also the blood sugars for eight to 12 hours after injection,” explained Dr. Spyros Mezitis, an endocrinologist and assistant professor of medicine at New York Presbyterian Hospital. “It has more flexibility.”

Patients only need two premix insulin injections: one before breakfast and one before dinner. The first injection take care of breakfast and lunch but disappears by dinner time, then a second injection will cover things until the next morning, explained study lead author Dr. Rehan Qayyum.

The premixed insulin analogues had also shown better results than long-acting insulin analogues and pills in reducing HbA1c (a blood-sugar control test performed normally after three months) and post-meal glucose levels.

For patients taking oral drugs, whose sugar level is not normal, “premixed analogue is one option that can be looked at instead of titrating up or manipulating these oral diabetic agents,” Qayyum said.