Methotrexate is commonly used for cancer treatment & for autoimmune diseases. Methotrexate is still in use for the remedy of neoplastic disorders, acute lymphoblastic leukemia etc. It is an antifolate & antimetabolite drug. It is involved in the tetrahydrofolate synthesis. It mainly helps in the DNA & RNA synthesis. It is also vastly used for rheumatoid arthritis, psoriasis etc. People should be made aware about all these side effects so that they can consult with a professional if prescribed.